Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.54 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | IDH2 | P48735 | 2/20 | 0.49 |
| ▸ | RHOA | P61586 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8978637 | 0.87 | NFKB1 (0.65) | KDRABCG2EGFR | |
| SCHEMBL2779096 | 0.87 | BRAF (0.52) | KDRABCG2EGFRADRB2 | |
| SCHEMBL29961547 | 0.84 | RAPGEF4 (0.61) | KDRABCG2RAPGEF4EGFREPAS1 | |
| SCHEMBL29961149 | 0.84 | RAPGEF4 (0.61) | KDRABCG2RAPGEF4EGFREPAS1 | |
| SCHEMBL1687027 | 0.84 | RAPGEF4 (0.61) | KDRABCG2RAPGEF4EGFREPAS1 | |
| SCHEMBL1984433 | 0.83 | KDR (0.55) | KDRABCG2RAPGEF4SYKEGFR | |
| SCHEMBL30490523 | 0.80 | NFKB1 (0.53) | KDREGFR | |
| SCHEMBL15606398 | 0.77 | GAA (0.68) | — | |
| SCHEMBL72905 | 0.77 | MEN1 (0.68) | ABCG2RAPGEF4ABCB1ABCC1EGFR | |
| SCHEMBL2456892 | 0.77 | ALDH1A1 (0.53) | KDRABCG2IDH2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189892-A1 | MELAMINE DERIVATIVES AS POTENT ANTI-CANCER AGENTS | Parker Hughes Institute (US) | 2002-03-27 | — | — | EP | claimed |
| US-6262053-B1 | EFFECTIVE FOR TREATING TUMOR CELLS AND PARTICULARLY EFFECTIVE TO INDUCE APOPTOSIS IN LEUKEMIA AND BREAST TUMOR CELLS. | PARKER HUGHES INSTITUTE | 2001-07-17 | — | — | US | claimed |
| WO-2000078738-A1 | MELAMINE DERIVATIVES AS POTENT ANTI-CANCER AGENTS | PARKER HUGHES INSTITUTE (US) | 2000-12-28 | — | — | WO | claimed |