Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.57 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.46 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.44 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415190 | 0.91 | KCNH2 (0.59) | KCNH2HDAC4CHRNA7ACACB | |
| SCHEMBL3347928 | 0.90 | KCNH2 (0.53) | KCNH2KCNQ3KCNQ2HDAC4TRPM8 | |
| SCHEMBL3350867 | 0.89 | KCNH2 (0.52) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3346204 | 0.87 | KCNH2 (0.54) | KCNH2HDAC4TRPM8 | |
| SCHEMBL3345898 | 0.87 | KCNH2 (0.54) | KCNH2HDAC4TRPM8 | |
| SCHEMBL3346506 | 0.87 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL13365060 | 0.86 | KCNH2 (0.52) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL13365073 | 0.85 | KCNH2 (0.50) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3346321 | 0.84 | KCNH2 (0.77) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3346727 | 0.84 | KCNH2 (0.53) | KCNH2HDAC4TRPM8ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |