Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346260 | 0.89 | KCNH2 (0.51) | KCNH2HDAC4TRPM8HRH3ROCK2 | |
| SCHEMBL3346204 | 0.87 | KCNH2 (0.54) | KCNH2HDAC4TRPM8HRH3SSTR4 | |
| SCHEMBL3346658 | 0.86 | KCNH2 (0.40) | KCNH2SSTR4ROCK2 | |
| SCHEMBL3348192 | 0.84 | KCNH2 (0.57) | KCNH2HDAC4TRPM8ACACB | |
| SCHEMBL3347928 | 0.82 | KCNH2 (0.53) | KCNH2HDAC4TRPM8ROCK2 | |
| SCHEMBL3353119 | 0.82 | KCNH2 (0.47) | KCNH2SSTR4PSEN1PSEN2APH1B | |
| SCHEMBL3347822 | 0.82 | KCNH2 (0.45) | KCNH2ROCK2 | |
| SCHEMBL3345898 | 0.81 | KCNH2 (0.54) | KCNH2HDAC4TRPM8HRH3SSTR4 | |
| SCHEMBL3415190 | 0.81 | KCNH2 (0.59) | KCNH2HDAC4HRH3ROCK2ACACB | |
| SCHEMBL3350867 | 0.81 | KCNH2 (0.52) | KCNH2TRPM8ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |