Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.37 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347928 | 0.90 | KCNH2 (0.53) | KCNH2ROCK2MAPK1KCNQ3KCNQ2 | |
| SCHEMBL3348192 | 0.89 | KCNH2 (0.57) | KCNH2KCNQ3KCNQ2KCNQ4KCNQ5 | |
| SCHEMBL3348168 | 0.88 | KCNH2 (0.45) | KCNH2ROCK2MAPK1KCNQ3KCNQ2 | |
| SCHEMBL3346506 | 0.88 | KCNH2 (0.51) | KCNH2ROCK2 | |
| SCHEMBL3346354 | 0.86 | KCNH2 (0.67) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3353009 | 0.86 | KCNH2 (0.67) | KCNH2ROCK2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3415190 | 0.84 | KCNH2 (0.59) | KCNH2ROCK2P2RX7 | |
| SCHEMBL3346383 | 0.82 | KCNH2 (0.50) | KCNH2ROCK2MAPK1KIT | |
| SCHEMBL3346727 | 0.81 | KCNH2 (0.53) | KCNH2ROCK2TRPM8 | |
| SCHEMBL3353108 | 0.81 | KCNH2 (0.46) | KCNH2ROCK2MAPK1KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |