Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 12/20 | 0.54 |
| ▸ | RIPK3 | Q9Y572 | 6/20 | 0.54 |
| ▸ | BRAF | P15056 | 8/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | PDGFA | P04085 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.52 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL825928 | 0.91 | RIPK1 (0.54) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL30317906 | 0.88 | RIPK1 (0.54) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL28498081 | 0.88 | RIPK1 (0.54) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL826861 | 0.86 | BRAF (0.60) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL2364582 | 0.85 | RIPK1 (0.52) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL3348325 | 0.79 | MEN1 (0.51) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL826741 | 0.78 | RIPK1 (0.52) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL28496453 | 0.77 | BRAF (0.64) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL30317917 | 0.77 | BRAF (0.64) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL28492957 | 0.77 | LMNA (0.52) | RIPK1RIPK3BRAFCHEK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064722-A1 | BENZOTHIAZOLE DERIVATIVES AS ANTICANCER AGENTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-10 | — | — | WO | disclosed |