Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | PDGFA | P04085 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348322 | 0.79 | RIPK1 (0.54) | MEN1MAPTKMT2ARIPK1RIPK3 | |
| SCHEMBL6431222 | 0.78 | RXFP1 (0.71) | MEN1MAPTKMT2ARXFP1KCNQ2 | |
| SCHEMBL825928 | 0.73 | RIPK1 (0.54) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL2364582 | 0.72 | RIPK1 (0.52) | MEN1MAPTKMT2ARIPK1RIPK3 | |
| SCHEMBL14340795 | 0.72 | RXFP1 (0.65) | MEN1MAPTKMT2ARXFP1KCNQ2 | |
| SCHEMBL30775042 | 0.72 | RXFP1 (0.58) | MEN1KMT2ARXFP1ALDH1A1GAA | |
| SCHEMBL6791603 | 0.72 | RXFP1 (0.58) | MEN1KMT2ARXFP1ALDH1A1GAA | |
| SCHEMBL30317906 | 0.71 | RIPK1 (0.54) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL28498081 | 0.71 | RIPK1 (0.54) | RIPK1RIPK3BRAFCHEK1IKBKB | |
| SCHEMBL7611403 | 0.69 | MEN1 (1.00) | MEN1MAPTKMT2ARXFP1KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064722-A1 | BENZOTHIAZOLE DERIVATIVES AS ANTICANCER AGENTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-10 | — | — | WO | disclosed |