Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23998613 | 0.86 | KDM4E (0.41) | SMN1; SMN2KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL31692752 | 0.86 | TDP2 (0.47) | ALDH1A1KDM4ENPC1RAB9AMAPT | |
| SCHEMBL23998385 | 0.85 | CYP19A1 (0.41) | SMN1; SMN2KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL30250866 | 0.83 | ALDH1A3 (0.47) | ALDH1A1HSD17B10 | |
| SCHEMBL23998434 | 0.83 | ALDH1A3 (0.47) | ALDH1A1HSD17B10 | |
| SCHEMBL23998500 | 0.81 | NPC1 (0.40) | L3MBTL1NPC1MAPT | |
| SCHEMBL2749583 | 0.79 | RAB9A (0.58) | SMN1; SMN2KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL23998453 | 0.78 | PTGS1 (0.44) | KMT2AMEN1L3MBTL1KDM4ETDP2 | |
| SCHEMBL3564589 | 0.75 | KDM4E (0.52) | ALDH1A1L3MBTL1KDM4EMAPTHSD17B10 | |
| SCHEMBL25331126 | 0.74 | AHR (0.38) | ALDH1A1L3MBTL1KDM4EHTTTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |