Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.52 |
| ▸ | APP | P05067 | 4/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3375494 | 0.89 | GPR119 (0.46) | GPR119APPESR1SLC6A9CYP2C9 | |
| SCHEMBL3343300 | 0.87 | GPR119 (0.69) | GPR119CYP2C9 | |
| SCHEMBL3285206 | 0.84 | GPR119 (0.65) | GPR119EPHX2HRH1CCR3 | |
| SCHEMBL3343666 | 0.83 | GPR119 (0.64) | GPR119CYP2C9 | |
| SCHEMBL3342683 | 0.81 | APP (0.46) | GPR119APPESR1CYP2C9HRH1 | |
| SCHEMBL3344012 | 0.80 | GPR119 (0.53) | GPR119EPHX2 | |
| Hydrochloric Acid SCHEMBL3347558 | 0.80 | APP (0.45) | GPR119APPESR1CYP2C9HRH1 | |
| SCHEMBL2556261 | 0.79 | GPR119 (0.73) | GPR119EPHX2HRH1 | |
| SCHEMBL14634420 | 0.79 | GPR119 (0.73) | GPR119EPHX2HRH1 | |
| SCHEMBL3344019 | 0.78 | GPR119 (0.61) | GPR119CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |