Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.46 |
| ▸ | APP | P05067 | 4/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348738 | 0.89 | GPR119 (0.52) | GPR119APPSLC6A9CYP2C9ESR1 | |
| SCHEMBL3344019 | 0.86 | GPR119 (0.61) | GPR119CYP2C9 | |
| SCHEMBL3343666 | 0.81 | GPR119 (0.64) | GPR119CYP2C9 | |
| Hydrochloric Acid SCHEMBL3342689 | 0.79 | PTGS2 (0.42) | GPR119APPCYP2C9ESR1CYP1A2 | |
| SCHEMBL3343300 | 0.79 | GPR119 (0.69) | GPR119CYP2C9 | |
| SCHEMBL3342683 | 0.78 | APP (0.46) | GPR119APPCYP2C9ESR1PTGS2 | |
| Hydrochloric Acid SCHEMBL3347558 | 0.77 | APP (0.45) | GPR119APPCYP2C9ESR1PTGS2 | |
| SCHEMBL3343980 | 0.76 | GPR119 (0.51) | GPR119PTGS2 | |
| SCHEMBL29768639 | 0.76 | ESR1 (0.49) | GPR119ESR1PTGS2PRKAB2PRKAG1 | |
| Hydrochloric Acid SCHEMBL3346673 | 0.76 | BCL9 (0.43) | GPR119APPESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |