Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.43 |
| ▸ | CCR5 | P51681 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAP2 | P11137 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726089 | 0.86 | ALDH1A1 (0.48) | GAARAD52KDM4EMAPTMAPK1 | |
| SCHEMBL2236367 | 0.84 | GAA (0.61) | GAARAD52CCR5KDM4EMAPT | |
| SCHEMBL2232603 | 0.81 | GAA (0.44) | GAARAD52CCR5KDM4EMAPT | |
| SCHEMBL3345200 | 0.81 | GAA (0.41) | GAARAD52KDM4EMAPTMAPK1 | |
| SCHEMBL15283334 | 0.80 | GAA (0.58) | GAARAD52KDM4EMAPTMAPK1 | |
| SCHEMBL1912004 | 0.79 | GAA (0.42) | GAARAD52CCR5KDM4EMAPT | |
| SCHEMBL10208073 | 0.78 | ALDH1A1 (0.54) | GAAKDM4EMAPTMAPK1HTT | |
| SCHEMBL15283576 | 0.77 | GAA (0.40) | GAARAD52CCR5KDM4EMAPT | |
| SCHEMBL3315044 | 0.77 | CASP6 (0.55) | MAPTALDH1A1GFER | |
| SCHEMBL3345906 | 0.76 | GAA (0.44) | GAARAD52KDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |