Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2726089 | 0.86 | ALDH1A1 (0.48) | GAARAD52ALDH1A1ADORA2BHTR4 | |
| SCHEMBL3346276 | 0.82 | MAPT (0.55) | ALDH1A1KDM4EMAPTMAPK1HTT | |
| SCHEMBL3349822 | 0.81 | GAA (0.43) | GAARAD52ALDH1A1KDM4EMAPT | |
| SCHEMBL3309942 | 0.80 | CASP6 (0.51) | ALDH1A1MAPT | |
| SCHEMBL3345906 | 0.79 | GAA (0.44) | GAARAD52ALDH1A1KDM4EMAPT | |
| SCHEMBL16935878 | 0.75 | MAP4K4 (0.44) | HTR1ADRD3 | |
| SCHEMBL17265652 | 0.75 | GAA (0.49) | GAARAD52ALDH1A1KDM4EMAPT | |
| SCHEMBL310404 | 0.75 | HTR4 (0.48) | GAARAD52HTR1AADORA2BHTR4 | |
| SCHEMBL15994391 | 0.74 | MAPT (0.46) | GAARAD52HTR1AALDH1A1ADORA2B | |
| SCHEMBL17265647 | 0.74 | CYP1A2 (0.51) | GAARAD52ALDH1A1HTR4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |