Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | BRS3 | P32247 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.43 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346492 | 0.90 | ROCK2 (0.46) | ROCK2KCNQ3KCNQ2KCNH2GPR139 | |
| SCHEMBL3346445 | 0.89 | KCNQ3 (0.50) | KCNQ3KCNQ2KCNH2GPR139RECQL | |
| SCHEMBL13365133 | 0.87 | ROCK2 (0.48) | ROCK2KCNQ3KCNQ2HDAC8MEN1 | |
| SCHEMBL3346676 | 0.86 | KCNQ3 (0.53) | ROCK2KCNQ3KCNQ2KCNH2GPR139 | |
| SCHEMBL3346373 | 0.84 | KCNH2 (0.57) | ROCK2KCNQ3KCNQ2KCNH2GPR139 | |
| SCHEMBL3346539 | 0.84 | KCNH2 (0.57) | ROCK2KCNQ3KCNQ2KCNH2GPR139 | |
| SCHEMBL3353138 | 0.83 | KCNQ3 (0.52) | ROCK2KCNQ3KCNQ2KCNH2GPR139 | |
| SCHEMBL13365126 | 0.81 | KCNH2 (0.52) | ROCK2KCNQ3KCNQ2KCNH2GPR139 | |
| SCHEMBL3346381 | 0.80 | SSTR4 (0.51) | KCNQ3KCNQ2KCNH2RECQLKCNQ4 | |
| SCHEMBL3346230 | 0.80 | KCNQ3 (0.66) | ROCK2KCNQ3KCNQ2KCNH2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |