Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | MC4R | P32245 | 4/20 | 0.39 |
| ▸ | PRCP | P42785 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | BRS3 | P32247 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3349846 | 0.90 | ROCK2 (0.48) | ROCK2KCNH2BRS3GAAHPGD | |
| SCHEMBL13365099 | 0.88 | KCNH2 (0.52) | ROCK2KCNH2SLC6A4MC4RPRCP | |
| SCHEMBL3353124 | 0.88 | KCNH2 (0.52) | ROCK2KCNH2SLC6A4MC4RPRCP | |
| SCHEMBL3353036 | 0.88 | KCNH2 (0.52) | ROCK2KCNH2SLC6A4MC4RPRCP | |
| SCHEMBL13365065 | 0.88 | KCNH2 (0.52) | ROCK2KCNH2SLC6A4MC4RPRCP | |
| SCHEMBL3353133 | 0.86 | KCNH2 (0.47) | ROCK2KCNH2SLC6A4MC4RMTOR | |
| SCHEMBL3353040 | 0.84 | KCNH2 (0.48) | ROCK2KCNH2SLC6A4MTORSMN1; SMN2 | |
| SCHEMBL3380842 | 0.83 | KCNH2 (0.40) | ROCK2KCNH2SLC6A4SMN1; SMN2PTGER4 | |
| SCHEMBL3353108 | 0.80 | KCNH2 (0.46) | ROCK2KCNH2KCNQ3KCNQ2 | |
| SCHEMBL13365133 | 0.79 | ROCK2 (0.48) | ROCK2SLC6A4DPP4KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |