Chloroxine

Chloroxine

SCHEMBL3350

Oc1c(Cl)cc(Cl)c2cccnc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 1.00
HSP90AA1 P07900 7/20 1.00
MEN1 O00255 6/20 1.00
HTT P42858 6/20 1.00
KMT2A Q03164 6/20 1.00
SMN1; SMN2 Q16637 6/20 1.00
TDP1 Q9NUW8 6/20 1.00
MAPT P10636 5/20 1.00
LMNA P02545 5/20 1.00
ALDH1A1 P00352 4/20 1.00
TP53 P04637 4/20 1.00
MMP14 P50281 3/20 1.00
OPRK1 P41145 3/20 1.00
ALOX15 P16050 3/20 1.00
SLC6A2 P23975 3/20 1.00
CYP3A4 P08684 2/20 1.00
ALOX12 P18054 2/20 1.00
ALOX15B O15296 1/20 1.00
NR1I2 O75469 1/20 1.00
HTR1A P08908 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chloroxine SCHEMBL29399997 1.00 KDM4E (1.00) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL29389908 1.00 KDM4E (1.00) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL6677225 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL9135479 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL22734873 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL4293183 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL231205 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL4297732 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL31016232 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL28905314 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2014 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4680240-A1 METHOD OF TREATING DISORDERS WITH SURF1 MALFUNCTION Cure Mito Foundation (US) 2026-01-21 EP claimed
WO-2025264604-A1 SKIN CARE COMPOSITION AND METHOD OF USING THE SAME THE PROCTER & GAMBLE COMPANY (US) 2025-12-26 WO claimed
US-20250381110-A1 SKIN CARE COMPOSITION AND METHOD OF USING THE SAME PROCTER & GAMBLE (US) 2025-12-18 US claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
WO-2024196831-A1 METHOD OF TREATING DISORDERS WITH SURF1 MALFUNCTION CURE MITO FOUNDATION (US) 2024-09-26 WO claimed
US-20240299450-A1 USES OF AMPHIPHILES IN IMMUNE CELL THERAPY AND COMPOSITIONS THEREFOR Elicio Therapeutics, Inc. 2024-09-12 US claimed
US-20240263135-A1 COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES FATE THERAPEUTICS, INC. 2024-08-08 US claimed
CN-118344408-A Nitrosyl ruthenium complex with hydroxyproline and 5, 7-dichloro-8-hydroxyquinoline as ligands, and preparation method and application thereof 山西大学 2024-07-16 CN claimed
CN-118206588-A 8-Hydroxyquinoline-triphenylphosphine rhodium (III) complex, synthesis method and application thereof 玉林师范学院 2024-06-18 CN claimed
US-11963955-B2 Compositions for and methods of inhibiting SARS-CoV2 infection TEXAS SOUTHERN UNIVERSITY (US) 2024-04-23 US claimed
EP-0046270-B1 NOVEL DERIVATIVES OF BIO-AFFECTING PHENOLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM INTERx RESEARCH CORPORATION (US) 1986-05-21 EP claimed
US-4520099-A CONTAINING AN HYDROXYQUINOLINE AS AN ANTIFOGGING AGENT FUJI PHOTO FILM CO., LTD. (JP) 1985-05-28 US claimed
EP-0096457-A1 Indium complexes of substituted 8-hydroxy-quinolines, pharmaceutical compositions containing them and their use as antibacterial agents NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1983-12-21 EP claimed
EP-0046270-A1 Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them INTERx RESEARCH CORPORATION (US) 1982-02-24 EP claimed
US-4228163-A WITH BENZOYL PEROXIDE AND 5-CHLORO-8-HYDROXYQUINOLINE DERMIK LABORATORIES (US) 1980-10-14 US claimed
US-4117013-A AMINES, QUATERNARY AMMONIUM COMPOUNDS, OLEFIN EPOXIDES, HYDROXYQUI(OLINES, AMINE PHENOXIDES, GLYCIDYL HALIDES AND ETHERS UNITED TECHNOLOGIES CORPORATION (US) 1978-09-26 US claimed
US-4038388-A A TETRACYCLINE AND A CHLORINATED 8-HYDROXYQUINOLINE, SYNERGISTIC PATERSON ZOCHONIS & COMPANY LIMITED (EN) 1977-07-26 US claimed
US-4025609-A CHELATION KAO SOAP CO., LTD. (JA) 1977-05-24 US claimed
US-4018918-A ANTIINFLAMMATORY, ANTIMICROBIAL AGENTS THE UPJOHN COMPANY (US) 1977-04-19 US claimed
US-3980778-A Anti-inflammatory steroid THE UPJOHN COMPANY (US) 1976-09-14 US claimed