Chloroxine

Chloroxine

SCHEMBL29399997

Oc1c(Cl)cc(Cl)c2cccnc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 1.00
HSP90AA1 P07900 7/20 1.00
MEN1 O00255 6/20 1.00
HTT P42858 6/20 1.00
KMT2A Q03164 6/20 1.00
SMN1; SMN2 Q16637 6/20 1.00
TDP1 Q9NUW8 6/20 1.00
MAPT P10636 5/20 1.00
LMNA P02545 5/20 1.00
ALDH1A1 P00352 4/20 1.00
TP53 P04637 4/20 1.00
MMP14 P50281 3/20 1.00
OPRK1 P41145 3/20 1.00
ALOX15 P16050 3/20 1.00
SLC6A2 P23975 3/20 1.00
CYP3A4 P08684 2/20 1.00
ALOX12 P18054 2/20 1.00
ALOX15B O15296 1/20 1.00
NR1I2 O75469 1/20 1.00
HTR1A P08908 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chloroxine SCHEMBL29389908 1.00 KDM4E (1.00) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL3350 1.00 KDM4E (1.00) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL6677225 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL9135479 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL22734873 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL4293183 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL231205 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL4297732 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL31016232 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A
Chloroxine SCHEMBL28905314 0.98 KDM4E (0.96) KDM4EHSP90AA1MEN1HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240180881-A1 METHODS FOR DECREASING RESISTANCE TO CHEMOTHERAPY NATIONAL INSTITUTE OF IMMUNOLOGY (IN) 2024-06-06 US claimed
WO-2023091964-A2 COMPOSITIONS AND METHODS FOR THE INHIBITION OF TUMOR METASTASIS AND HORIZONTAL GENE TRANSFER THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) 2023-05-25 WO claimed
EP-4057813-A1 COMPOSITIONS AND METHODS FOR TREATING HUANGLONGBING DISEASE IN CITRUS New Life Crop Sciences LLC (US) 2022-09-21 EP claimed
WO-2026090318-A2 ENCAPSULATION COMPOSITIONS AND METHODS FOR ENCAPSULATING ACTIVE AGENTS DEFY-Tech Labs, Inc. (US) 2026-04-30 WO disclosed
US-20260108446-A1 HYDROXYQUINOLINE COMPOUNDS AND METHODS OF USE AS PIGMENT MODIFYING AGENTS GERMANAS JURIS (US) 2026-04-23 US disclosed
US-20260108444-A1 ENCAPSULATION COMPOSITIONS AND METHODS FOR ENCAPSULATING ACTIVE AGENTS DEFY TECH LABS INC (US) 2026-04-23 US disclosed
US-20260102359-A1 COMBINATION TREATMENT OF DERMAL AND TRANSDERMAL FIBROTIC DISEASES, DISORDERS AND ASSOCIATED PAIN AND INFLAMMATION ERESINA LLC (US) 2026-04-16 US disclosed
US-12590963-B2 Anti-cancer treatment of preselected subjects and screening methods to identify susceptible subjects TUDAG TU DRESDEN AKTIENGESELLSCHAFT (DE) 2026-03-31 US disclosed
US-20260085341-A1 Using Multiple Heteroresistance to Guide Combination Antimicrobial Regimens UNIV EMORY (US) 2026-03-26 US disclosed
EP-4706683-A2 CHEWABLE FORMULATIONS Elanco Tiergesundheit AG (CH) 2026-03-11 EP disclosed
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES AQUESTIVE THERAPEUTICS, INC. (US) 2026-02-05 US disclosed
US-11400106-B2 Methods for inhibiting microbe growth MCMASTER UNIVERSITY (CA) 2022-08-02 US disclosed
US-20220233471-A1 PRODRUG COMPOSITIONS AND METHODS OF TREATMENT AQUESTIVE THERAPEUTICS, INC. (US) 2022-07-28 US disclosed
WO-2022155544-A1 PRODRUG COMPOSITIONS AND METHODS OF TREATMENT AQUESTIVE THERAPEUTICS, INC. (US) 2022-07-21 WO disclosed
US-11377442-B2 Small molecule agonists and antagonists of NR2F6 activity Zander Biologics, Inc (US) 2022-07-05 US disclosed
US-20220168384-A1 Anti-Bacterial Combination Therapy MCMASTER UNIVERSITY (CA) 2022-06-02 US disclosed
US-11324719-B2 Small molecule agonists and antagonists of NR2F6 activity in humans KCL THERAPEUTICS, INC. (US) 2022-05-10 US disclosed
WO-2022049149-A1 CHEWABLE FORMULATIONS ELANCO TIERGESUNDHEIT AG (CH) 2022-03-10 WO disclosed
EP-3960729-A1 COMPOUNDS AND METHODS OF TREATING INFECTIONS Neoculi Pty Ltd (AU) 2022-03-02 EP disclosed
US-11241427-B2 Small molecule modulators of NR2F6 activity KCL THERAPEUTICS, INC. (US) 2022-02-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260108444-A1 ENCAPSULATION COMPOSITIONS AND METHODS FOR ENCAPSULATING ACTIVE AGENTS LIPA, LIPC, ACACA KDM4E 2194/4885HSP90AA1 1683/4885MEN1 3824/4885
US-20260085341-A1 Using Multiple Heteroresistance to Guide Combination Antimicrobial Regimens Q6ZSR9, AMPD2, AMPD1 KDM4E 1937/4885HSP90AA1 1124/4885MEN1 3172/4885
US-20220233471-A1 PRODRUG COMPOSITIONS AND METHODS OF TREATMENT CYP2C19, PAICS, CYP2B6 KDM4E 3899/4885HSP90AA1 2775/4885MEN1 2692/4885
US-20260108446-A1 HYDROXYQUINOLINE COMPOUNDS AND METHODS OF USE AS PIGMENT MODIFYING AGENTS TYR, TFEB, MC1R KDM4E 1218/4885HSP90AA1 2473/4885MEN1 3765/4885
US-11241427-B2 Small molecule modulators of NR2F6 activity NR2F2, NR2E3, NR2C2 KDM4E 1747/4885HSP90AA1 3378/4885MEN1 4656/4885
US-11400106-B2 Methods for inhibiting microbe growth MMP8, BPGM, CAPG KDM4E 3158/4885HSP90AA1 962/4885MEN1 2205/4885
US-20260034059-A1 ORAL FILM COMPOSITIONS AND DOSAGE FORMS HAVING PRECISE ACTIVE DISSOLUTION PROFILES SORD, SLC6A13, CACNA1A KDM4E 1515/4885HSP90AA1 2910/4885MEN1 2827/4885
US-20260102359-A1 COMBINATION TREATMENT OF DERMAL AND TRANSDERMAL FIBROTIC DISEASES, DISORDERS AND ASSOCIATED PAIN AND INFLAMMATION COL2A1, COLGALT1, PLOD3 KDM4E 2468/4885HSP90AA1 1524/4885MEN1 4053/4885
US-20240180881-A1 METHODS FOR DECREASING RESISTANCE TO CHEMOTHERAPY BLM, RAD54L, XRCC5 KDM4E 1367/4885HSP90AA1 2960/4885MEN1 1182/4885
US-11324719-B2 Small molecule agonists and antagonists of NR2F6 activity in humans NR4A2, NR2C2, NR0B2 KDM4E 3440/4885HSP90AA1 2110/4885MEN1 3917/4885
US-11377442-B2 Small molecule agonists and antagonists of NR2F6 activity NR4A2, NR2C2, NR2F2 KDM4E 3502/4885HSP90AA1 2026/4885MEN1 4260/4885
US-20220168384-A1 Anti-Bacterial Combination Therapy TST, SLC11A2, HAMP KDM4E 4127/4885HSP90AA1 173/4885MEN1 4295/4885
US-12590963-B2 Anti-cancer treatment of preselected subjects and screening methods to identify susceptible subjects TPM4, TPM3, TAGLN2 KDM4E 2931/4885HSP90AA1 931/4885MEN1 2154/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.