Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DDO | Q99489 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14317221 | 0.90 | ALDH1A1 (0.44) | ALDH1A1KDM4EPTGS1PTGS2DAO | |
| SCHEMBL3349053 | 0.88 | ALDH1A1 (0.45) | ALDH1A1KDM4EALKBH3PTGS1PTGS2 | |
| SCHEMBL3345086 | 0.83 | ALKBH3 (0.42) | ALDH1A1KDM4EALKBH3DAOMAPT | |
| SCHEMBL15931677 | 0.82 | KDM4E (0.47) | ALDH1A1KDM4EDAOHSD17B10MAPT | |
| SCHEMBL3349059 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4EALKBH3DAOMAPT | |
| SCHEMBL3343713 | 0.79 | PDE10A (0.41) | ALDH1A1KDM4EALKBH3DAOHSD17B10 | |
| SCHEMBL3347965 | 0.78 | ALDH1A1 (0.48) | ALDH1A1KDM4EALKBH3HSD17B10USP2 | |
| SCHEMBL3345122 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4EALKBH3PTGS1PTGS2 | |
| SCHEMBL3344021 | 0.78 | AKR1B1 (0.39) | DAONPSR1DDOMEN1KMT2A | |
| SCHEMBL6584194 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EHSD17B10MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |