Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 15/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 9/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.43 |
| ▸ | PRKACA | P17612 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | PRKX | P51817 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | PRKACG | P22612 | 2/20 | 0.41 |
| ▸ | PRKACB | P22694 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346217 | 0.89 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL3346572 | 0.89 | KCNH2 (0.51) | KCNH2ROCK2ROCK1MAPK1 | |
| SCHEMBL3346383 | 0.88 | KCNH2 (0.50) | KCNH2ROCK2ROCK1MAPK1 | |
| SCHEMBL13365135 | 0.87 | KCNH2 (0.57) | KCNH2 | |
| SCHEMBL3346689 | 0.87 | POLB (0.50) | POLBMEN1LMNAHTTKMT2A | |
| SCHEMBL3346490 | 0.87 | KCNH2 (0.65) | KCNH2POLBMEN1LMNAHTT | |
| SCHEMBL3346552 | 0.83 | KCNH2 (0.45) | KCNH2ROCK2ROCK1 | |
| SCHEMBL3346506 | 0.83 | KCNH2 (0.51) | KCNH2POLBMEN1LMNAHTT | |
| SCHEMBL3346567 | 0.83 | KCNH2 (0.59) | KCNH2KMT2AMAPK1 | |
| SCHEMBL3347178 | 0.80 | KCNH2 (0.53) | KCNH2POLBMEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |