Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | MST1R | Q04912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350804 | 0.90 | MAPK1 (0.41) | ROCK2ROCK1KIT | |
| SCHEMBL13365057 | 0.88 | KCNH2 (0.38) | POLBROCK2KITSMN1; SMN2 | |
| SCHEMBL3380842 | 0.87 | KCNH2 (0.40) | ROCK2ROCK1KITSMN1; SMN2 | |
| SCHEMBL3350854 | 0.87 | KCNH2 (0.49) | POLBROCK2PRKG1MEN1KMT2A | |
| SCHEMBL3349710 | 0.86 | KCNQ3 (0.46) | LMNASMN1; SMN2 | |
| SCHEMBL3346274 | 0.86 | POLB (0.54) | POLBROCK2PRKG1MEN1KMT2A | |
| SCHEMBL3347954 | 0.84 | POLB (0.54) | POLBROCK2PRKG1MEN1KMT2A | |
| SCHEMBL3352431 | 0.84 | ROCK2 (0.52) | POLBROCK2PRKG1MEN1KMT2A | |
| SCHEMBL3350848 | 0.82 | ROCK2 (0.41) | ROCK2ROCK1 | |
| SCHEMBL3350882 | 0.81 | KCNH2 (0.46) | MEN1KMT2AKITSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |