Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 7/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347239 | 0.84 | DYRK1A (0.45) | DYRK1ATGFBR1GRM5SCN5ANPC1 | |
| SCHEMBL3348904 | 0.83 | TGFBR1 (0.46) | DYRK1ATGFBR1GRM5SCN5AKDM4E | |
| SCHEMBL3352946 | 0.81 | DYRK1A (0.40) | DYRK1ATGFBR1SCN5APIK3CD | |
| SCHEMBL3346215 | 0.81 | DYRK1A (0.38) | DYRK1ATGFBR1SCN5A | |
| SCHEMBL3346724 | 0.80 | GRM5 (0.46) | DYRK1AGRM5CYP1A2 | |
| SCHEMBL3347287 | 0.80 | DYRK1A (0.44) | DYRK1ATGFBR1GRM5SCN5AKDM4E | |
| SCHEMBL3347011 | 0.80 | DYRK1A (0.41) | DYRK1ATGFBR1GRM5KCNH2SCN5A | |
| SCHEMBL3346984 | 0.80 | DYRK1A (0.41) | DYRK1ATGFBR1GRM5SCN5AKDM4E | |
| SCHEMBL3346973 | 0.80 | DYRK1A (0.41) | DYRK1ATGFBR1GRM5SCN5A | |
| SCHEMBL3347027 | 0.79 | GRM5 (0.50) | DYRK1ATGFBR1GRM5KCNH2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |