SCHEMBL3352185 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	LRRK2	Q5S007	7/20	0.39

▸	HPGD	P15428	1/20	0.37

▸	SSTR4	P31391	1/20	0.35

▸	MAPK8	P45983	1/20	0.35

▸	MAPK9	P45984	1/20	0.35

▸	MAPK10	P53779	1/20	0.35

▸	PDE4B	Q07343	1/20	0.35

▸	DUT	P33316	3/20	0.34

▸	FFAR4	Q5NUL3	1/20	0.34

▸	DRD2	P14416	2/20	0.34

▸	DRD3	P35462	2/20	0.34

▸	BRD4	O60885	1/20	0.33

▸	ACACB	O00763	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3352192	1.00	LRRK2 (0.39)	LRRK2HPGDSSTR4MAPK8MAPK9
SCHEMBL3345752	0.85	LRRK2 (0.39)	LRRK2
SCHEMBL3345749	0.85	LRRK2 (0.39)	LRRK2
SCHEMBL3345353	0.85	LRRK2 (0.41)	LRRK2HPGDSSTR4MAPK8MAPK9
SCHEMBL3345358	0.85	LRRK2 (0.41)	LRRK2HPGDSSTR4MAPK8MAPK9
SCHEMBL3378674	0.82	TLR9 (0.40)	LRRK2DUTBRD4
SCHEMBL3347090	0.77	RORC (0.40)	ACACB
SCHEMBL3347085	0.77	RORC (0.40)	ACACB
SCHEMBL3345689	0.77	LRRK2 (0.37)	LRRK2SSTR4
SCHEMBL3345692	0.77	LRRK2 (0.37)	LRRK2SSTR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2010046388-A1	SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS	GLAXO GROUP LIMITED (GB)	2010-04-29	—	—	WO	disclosed
WO-2010045987-A1	SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS	GLAXO GROUP LIMITED (GB)	2010-04-29	—	—	WO	disclosed