Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347090 | 1.00 | RORC (0.40) | RORCPDE4DCNR2NPC1RAB9A | |
| SCHEMBL3345353 | 0.88 | LRRK2 (0.41) | RORCKCNH2HRH3 | |
| SCHEMBL3345358 | 0.88 | LRRK2 (0.41) | RORCKCNH2HRH3 | |
| SCHEMBL3352400 | 0.87 | KCNH2 (0.41) | RORCPDE4DKCNH2 | |
| SCHEMBL3352394 | 0.87 | KCNH2 (0.41) | RORCPDE4DKCNH2 | |
| SCHEMBL3345752 | 0.84 | LRRK2 (0.39) | RORCCRHR1CRHR2HRH3 | |
| SCHEMBL3345749 | 0.84 | LRRK2 (0.39) | RORCCRHR1CRHR2HRH3 | |
| SCHEMBL3379792 | 0.83 | RORC (0.38) | RORCPDE4DCNR2 | |
| SCHEMBL3379795 | 0.83 | RORC (0.38) | RORCPDE4DCNR2 | |
| SCHEMBL3345689 | 0.83 | LRRK2 (0.37) | KCNH2CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010046388-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010045987-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |