Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345358 | 1.00 | LRRK2 (0.41) | LRRK2HPGDHRH3DHODHRORC | |
| SCHEMBL3345752 | 0.92 | LRRK2 (0.39) | LRRK2HRH3RORCGRIN2BCYP4F2 | |
| SCHEMBL3345749 | 0.92 | LRRK2 (0.39) | LRRK2HRH3RORCGRIN2BCYP4F2 | |
| SCHEMBL3347085 | 0.88 | RORC (0.40) | HRH3RORCKCNH2 | |
| SCHEMBL3347090 | 0.88 | RORC (0.40) | HRH3RORCKCNH2 | |
| SCHEMBL3352394 | 0.87 | KCNH2 (0.41) | LRRK2RORCKCNH2SSTR4 | |
| SCHEMBL3352400 | 0.87 | KCNH2 (0.41) | LRRK2RORCKCNH2SSTR4 | |
| SCHEMBL3352185 | 0.85 | LRRK2 (0.39) | LRRK2HPGDSSTR4MAPK8MAPK9 | |
| SCHEMBL3352192 | 0.85 | LRRK2 (0.39) | LRRK2HPGDSSTR4MAPK8MAPK9 | |
| SCHEMBL3375050 | 0.83 | TLR9 (0.40) | LRRK2HRH3RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010046388-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010045987-A1 | SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-29 | — | — | WO | disclosed |