Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.52 |
| ▸ | PRKG1 | Q13976 | 7/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | MST1R | Q04912 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348168 | 0.89 | KCNH2 (0.45) | ROCK2PRKG1CHRNA7KCNH2 | |
| SCHEMBL13365125 | 0.88 | KCNH2 (0.44) | ROCK2PRKG1CHRNA7KCNH2 | |
| SCHEMBL3346274 | 0.88 | POLB (0.54) | ROCK2PRKG1POLBSMN1; SMN2KCNH2 | |
| SCHEMBL3353108 | 0.87 | KCNH2 (0.46) | ROCK2PRKG1CHRNA7KCNH2 | |
| SCHEMBL3346506 | 0.87 | KCNH2 (0.51) | ROCK2PRKG1POLBROCK1SMN1; SMN2 | |
| SCHEMBL13364987 | 0.87 | ROCK2 (0.48) | ROCK2PRKG1POLBROCK1PRKACA | |
| SCHEMBL13365073 | 0.86 | KCNH2 (0.50) | ROCK2CHRNA7KCNH2 | |
| SCHEMBL3353232 | 0.86 | POLB (0.53) | ROCK2PRKG1POLBROCK1SMN1; SMN2 | |
| SCHEMBL3347954 | 0.86 | POLB (0.54) | ROCK2PRKG1POLBROCK1SMN1; SMN2 | |
| SCHEMBL3346689 | 0.84 | POLB (0.50) | ROCK2PRKG1POLBROCK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |