Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 3/20 | 0.45 |
| ▸ | F7 | P08709 | 2/20 | 0.38 |
| ▸ | F3 | P13726 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 4/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | EIF2S1 | P05198 | 1/20 | 0.35 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL335522 | 0.93 | F9 (0.53) | F9F7F3INSRLCK | |
| SCHEMBL362059 | 0.86 | F9 (0.40) | F9F7F3NPC1HDAC1 | |
| SCHEMBL335037 | 0.85 | F9 (0.55) | F9F7F3RAB9AF10 | |
| SCHEMBL335437 | 0.81 | F10 (0.46) | F9F7F3HDAC1F10 | |
| SCHEMBL335890 | 0.81 | ACP1 (0.40) | F9F7F3INSRLCK | |
| SCHEMBL334954 | 0.80 | F9 (0.47) | F9F7F3F10ROCK2 | |
| SCHEMBL335322 | 0.78 | F9 (0.64) | F9F7F3RAB9AF10 | |
| SCHEMBL8223612 | 0.78 | F9 (0.40) | F9F7F3F10EIF2S1 | |
| SCHEMBL334986 | 0.77 | MAPT (0.44) | F9F7F3NPC1RAB9A | |
| SCHEMBL335901 | 0.77 | F10 (0.47) | F9F7F3F10ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097758-B2 | Isoserine derivatives for use as coagulation factor IXa inhibitors | SANOFI-AVENTIS (FR) | 2012-01-17 | — | — | US | claimed |