SCHEMBL33527205

SCHEMBL33527205

Cn1c(=O)[nH]c2cc(C#N)c(Cl)nc21

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.53
MEN1 O00255 1/20 0.53
PABPC1 P11940 1/20 0.53
KMT2A Q03164 1/20 0.53
PDE3B Q13370 4/20 0.44
PDE3A Q14432 4/20 0.44
GAA P10253 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37
KHK P50053 1/20 0.36
P2RY12 Q9H244 2/20 0.36
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
IDH1 O75874 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KDM5A P29375 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30232288 0.70 JAK1 (0.43) LMNAMEN1KMT2AMAPT
SCHEMBL15168625 0.70 GRM2 (0.54) LMNAMEN1PABPC1KMT2APDE3B
SCHEMBL18536694 0.69 PDE3B (0.51) LMNAMEN1PABPC1KMT2APDE3B
SCHEMBL31217710 0.68 KDM4E (0.58) LMNAMEN1PABPC1KMT2APDE3B
SCHEMBL5329685 0.68 KDM4E (0.58) LMNAMEN1PABPC1KMT2APDE3B
SCHEMBL31425667 0.68 LMNA (0.62) LMNAMEN1PABPC1KMT2APDE3B
SCHEMBL5043253 0.68 ALDH1A1 (0.43) LMNAGAAKDM4EALDH1A1KHK
SCHEMBL23357368 0.67 ALDH1A1 (0.41) GAAKDM4EALDH1A1MAPTKHK
SCHEMBL29864436 0.67 LMNA (0.60) LMNAMEN1PABPC1KMT2APDE3B
SCHEMBL30711996 0.67 ALDH1A1 (0.41) GAAKDM4EALDH1A1MAPTKHK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260091048-A1 GIP RECEPTOR AGONIST COMPOUNDS LILLY CO ELI (US) 2026-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260091048-A1 GIP RECEPTOR AGONIST COMPOUNDS GIPR, GLP1R, GPR119 LMNA 2816/4885MEN1 3404/4885PABPC1 3774/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.