Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 7/20 | 0.44 |
| ▸ | DRD3 | P35462 | 6/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13217157 | 0.90 | MMP2 (0.45) | CYP11B1PKMJAK2ALDH1A1MCOLN3 | |
| SCHEMBL17165071 | 0.90 | CYP11B1 (0.52) | CYP11B1PKMJAK2ALDH1A1MCOLN3 | |
| SCHEMBL17165088 | 0.87 | KMT2A (0.51) | CYP11B1PKMJAK2ALDH1A1MCOLN3 | |
| SCHEMBL17165060 | 0.87 | KMT2A (0.51) | CYP11B1PKMJAK2ALDH1A1MCOLN3 | |
| SCHEMBL17165084 | 0.86 | CYP11B1 (0.52) | CYP11B1PKMJAK2ALDH1A1MCOLN3 | |
| SCHEMBL17165101 | 0.86 | CYP11B1 (0.49) | CYP11B1PKMJAK2ALDH1A1MCOLN3 | |
| SCHEMBL17165086 | 0.84 | PKM (0.43) | CYP11B1PKMJAK2ALDH1A1MCOLN3 | |
| SCHEMBL13005132 | 0.84 | CYP11B1 (0.48) | CYP11B1PKMJAK2ALDH1A1MCOLN3 | |
| SCHEMBL9908323 | 0.84 | CYP11B1 (0.48) | CYP11B1PKMJAK2ALDH1A1MCOLN3 | |
| SCHEMBL17173462 | 0.84 | CYP11B1 (0.54) | CYP11B1PKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107001354-B | Histone deacetylase inhibitors | 台北医学大学 | 2021-06-22 | — | — | CN | disclosed |
| US-10246455-B2 | Histone deacetylase inhibitors | TAIPEI MEDICAL UNIVERSITY (TW) | 2019-04-02 | — | — | US | disclosed |
| US-10246455-B2 | Histone deacetylase inhibitors | TAIPEI MEDICAL UNIVERSITY (TW) | 2019-04-02 | — | — | US | disclosed |
| US-20170057956-A1 | HISTONE DEACETYLASE INHIBITORS | TAIPEI MEDICAL UNIVERSITY (TW) | 2017-03-02 | — | — | US | disclosed |
| US-20170057956-A1 | HISTONE DEACETYLASE INHIBITORS | TAIPEI MEDICAL UNIVERSITY (TW) | 2017-03-02 | — | — | US | disclosed |
| US-20170057956-A1 | HISTONE DEACETYLASE INHIBITORS | TAIPEI MEDICAL UNIVERSITY (TW) | 2017-03-02 | — | — | US | disclosed |
| EP-3129373-A1 | HISTONE DEACETYLASE INHIBITORS | Taipei Medical University (TW) | 2017-02-15 | — | — | EP | disclosed |
| WO-2015157504-A1 | HISTONE DEACETYLASE INHIBITORS | TAIPEI MEDICAL UNIVERSITY (TW) | 2015-10-15 | — | — | WO | disclosed |
| WO-2015157504-A1 | HISTONE DEACETYLASE INHIBITORS | TAIPEI MEDICAL UNIVERSITY (TW) | 2015-10-15 | — | — | WO | disclosed |
| EP-1633750-B1 | SYNTHESIS OF 5-SUBSTITUTED 7-AZAINDOLES AND 7-AZAINDOLINES | EISAI R&D MAN CO LTD (JP) | 2010-12-01 | — | — | EP | disclosed |
| US-7652137-B2 | Substitued azaindoline intermediate for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles; pharmaceutical intermediates | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2010-01-26 | — | — | US | disclosed |
| US-7652137-B2 | Substitued azaindoline intermediate for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles; pharmaceutical intermediates | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2010-01-26 | — | — | US | disclosed |
| US-20060235042-A1 | Synthesis | EISAI CO., LTD. (JP) | 2006-10-19 | — | — | US | disclosed |
| EP-1633750-A2 | SYNTHESIS OF 5-SUBSTITUTED 7-AZAINDOLES AND 7-AZAINDOLINES | Eisai Co., Ltd. (JP) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004078757-A2 | SYNTHESIS OF 5-SUBSTITUTED 7-AZAINDOLES AND 7-AZAIDONINES | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10246455-B2 | Histone deacetylase inhibitors | HDAC1, HDAC2, HDAC5 | CYP11B1 480/4885PKM 908/4885JAK2 1636/4885 |
| US-20060235042-A1 | Synthesis | AZI2, CYP3A5, CYP3A7 | CYP11B1 211/4885PKM 2984/4885JAK2 1555/4885 |
| US-20170057956-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC2, HDAC5 | CYP11B1 480/4885PKM 908/4885JAK2 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.