Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 15/20 | 1.00 |
| ▸ | CTSS | P25774 | 3/20 | 1.00 |
| ▸ | CTSC | P53634 | 3/20 | 1.00 |
| ▸ | CTSZ | Q9UBR2 | 3/20 | 1.00 |
| ▸ | CTSV | O60911 | 2/20 | 1.00 |
| ▸ | CTSH | P09668 | 2/20 | 1.00 |
| ▸ | CTSK | P43235 | 2/20 | 1.00 |
| ▸ | CASP1 | P29466 | 2/20 | 1.00 |
| ▸ | KLK4 | Q9Y5K2 | 2/20 | 0.57 |
| ▸ | CTSB | P07858 | 1/20 | 0.57 |
| ▸ | CASP4 | P49662 | 1/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350703 | 0.83 | CTSV (0.71) | CTSLCTSSCTSCCTSZCTSV | |
| SCHEMBL13363712 | 0.83 | CTSV (0.71) | CTSLCTSSCTSCCTSZCTSV | |
| SCHEMBL4847855 | 0.81 | CTSL (0.68) | CTSLCTSSCTSCCTSZCTSV | |
| SCHEMBL3346407 | 0.68 | CTSL (1.00) | CTSLCTSSCTSCCTSZCTSV | |
| SCHEMBL5441670 | 0.65 | CTSL (0.50) | CTSLCTSSCTSCCTSZCTSV | |
| SCHEMBL4848081 | 0.64 | CTSL (0.48) | CTSLCTSSCTSCCTSZCTSV | |
| SCHEMBL3350716 | 0.63 | CTSV (0.45) | CTSLCTSSCTSCCTSZCTSV | |
| SCHEMBL3441067 | 0.62 | CCNE2 (0.58) | CTSLCTSSCTSCCTSZCTSV | |
| SCHEMBL31061476 | 0.61 | CTSL (1.00) | CTSLCTSB | |
| SCHEMBL4849083 | 0.60 | CTSL (0.45) | CTSLCTSSCTSCCTSZCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059418-A1 | SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS | THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) | 2010-05-27 | — | — | WO | disclosed |