SCHEMBL3350703

SCHEMBL3350703

CCNc1nc(Cl)nc2c1ncn2-c1cc(F)cc(F)c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSV O60911 1/20 0.71
CTSL P07711 1/20 0.71
CTSH P09668 1/20 0.71
CTSS P25774 1/20 0.71
CASP1 P29466 1/20 0.71
CTSK P43235 1/20 0.71
CTSC P53634 1/20 0.71
CTSZ Q9UBR2 1/20 0.71
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
TSHR P16473 1/20 0.50
CYP2C19 P33261 1/20 0.50
ADORA3 P0DMS8 3/20 0.47
ADORA1 P30542 2/20 0.47
HDAC3 O15379 3/20 0.45
HDAC4 P56524 3/20 0.45
HDAC1 Q13547 3/20 0.45
HDAC7 Q8WUI4 3/20 0.45
HDAC2 Q92769 3/20 0.45
HDAC10 Q969S8 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13363712 0.85 CTSV (0.71) CTSVCTSLCTSHCTSSCASP1
SCHEMBL3353019 0.83 CTSL (1.00) CTSVCTSLCTSHCTSSCASP1
SCHEMBL3350716 0.78 CTSV (0.45) CTSVCTSLCTSHCTSSCASP1
SCHEMBL3441067 0.78 CCNE2 (0.58) CTSVCTSLCTSHCTSSCASP1
SCHEMBL15756901 0.76 YTHDC1 (0.69) ADORA3ADORA1HDAC3HDAC4HDAC1
SCHEMBL24966176 0.72 CDK1 (0.69) ADORA3ADORA1CDK1CDK2
SCHEMBL8348688 0.71 HDAC1 (0.64) CTSLADORA3ADORA1HDAC3HDAC4
SCHEMBL27148924 0.71 CYP2D6 (0.56) CYP2D6CYP2C9TSHRCYP2C19ADORA3
SCHEMBL6818080 0.68 ADORA3 (0.61) CTSLADORA3ADORA1YTHDC1CDK1
SCHEMBL4847855 0.68 CTSL (0.68) CTSVCTSLCTSHCTSSCASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024105159-A1 LIGANDS OF THE M6A-RNA READERS UNIVERSITY OF ZURICH (CH) 2024-05-23 WO disclosed
WO-2010059418-A1 SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) 2010-05-27 WO disclosed
WO-2010059418-A1 SUBSTITUTED TRIAZINE AND PURINE COMPOUNDS, METHODS OF INHIBITING CRUZAIN AND RHODESAIN AND METHODS OF TREATING CHAGAS DISEASE AND AFRICAN TRYPANOSOMIASIS THE GOVERNMENT OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH & HUMAN SERVICES (US) 2010-05-27 WO disclosed