Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 16/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17495546 | 0.90 | RORC (0.50) | RORCDRD2SLC6A4HTR1DHTR1B | |
| SCHEMBL17495380 | 0.86 | RORC (0.64) | RORC | |
| SCHEMBL17495381 | 0.85 | RORC (0.48) | RORCDRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL17495540 | 0.85 | RORC (0.63) | RORC | |
| SCHEMBL3352752 | 0.84 | HTR1B (0.57) | RORCDRD2SLC6A4HTR1DHTR1B | |
| SCHEMBL17495399 | 0.84 | SCN9A (0.57) | RORCDRD2SLC6A4KDM4EALDH1A1 | |
| SCHEMBL5937364 | 0.82 | ALDH1A1 (0.57) | RORCKDM4EBRD4ALDH1A1POLB | |
| SCHEMBL17060397 | 0.81 | DRD2 (0.49) | RORCDRD2SLC6A4KDM4EALDH1A1 | |
| SCHEMBL3351361 | 0.81 | DRD2 (0.50) | RORCDRD2SLC6A4HTR1DHTR1B | |
| SCHEMBL17495523 | 0.80 | SCN9A (0.53) | RORCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |