Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 3/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353056 | 1.00 | KMT2A (0.50) | KMT2ALMNAKDM4EMEN1TSHR | |
| SCHEMBL3347845 | 0.88 | MGLL (0.47) | KMT2ALMNAMGLLTRPV1TRPM8 | |
| SCHEMBL3347840 | 0.88 | MGLL (0.47) | KMT2ALMNAMGLLTRPV1TRPM8 | |
| SCHEMBL2427670 | 0.87 | KMT2A (0.48) | KMT2ALMNAKDM4EMEN1TSHR | |
| SCHEMBL2338358 | 0.86 | KMT2A (0.53) | KMT2ALMNAKDM4EMEN1TSHR | |
| SCHEMBL2427378 | 0.83 | KMT2A (0.44) | KMT2ALMNAKDM4EMEN1TSHR | |
| SCHEMBL2432969 | 0.83 | KMT2A (0.44) | KMT2ALMNAKDM4EMEN1TSHR | |
| SCHEMBL2424231 | 0.82 | KMT2A (0.43) | KMT2ALMNAKDM4EMEN1TSHR | |
| Hydrochloric Acid SCHEMBL2424245 | 0.81 | KMT2A (0.47) | KMT2ALMNAKDM4EMEN1TSHR | |
| SCHEMBL2427671 | 0.80 | KMT2A (0.46) | KMT2ALMNAKDM4EMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058318-A1 | 1-OXA-8-AZASPIRO [4, 5 ] DECANE- 8 -CARBOXAMIDE COMPOUNDS AS FAAH INHIBITORS | PFIZER INC. (US) | 2010-05-27 | — | — | WO | disclosed |