Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28046310 | 0.80 | NCOA3 (0.56) | NOTUMHRH3KDM4EALDH1A1MAPK1 | |
| SCHEMBL27389898 | 0.78 | EGFR (0.51) | EGFRPIK3CDPIK3CAMKNK2NCOA3 | |
| SCHEMBL27837893 | 0.74 | NCOA3 (0.66) | EGFRNOTUMMKNK2NCOA3 | |
| SCHEMBL27565523 | 0.73 | CYP11B1 (0.56) | NOTUMHRH3KDM4EALDH1A1MAPK1 | |
| SCHEMBL27867723 | 0.72 | NOTUM (0.41) | NOTUMHRH3PIK3CDPIK3CAKDM4E | |
| SCHEMBL28093134 | 0.72 | LMNA (0.41) | NOTUMHRH3KDM4EALDH1A1MAPK1 | |
| SCHEMBL6779647 | 0.72 | NOTUM (0.50) | NOTUMHRH3KDM4EALDH1A1MAPK1 | |
| SCHEMBL3665773 | 0.72 | NOTUM (0.53) | NOTUMHRH3KDM4EALDH1A1MAPK1 | |
| SCHEMBL3974447 | 0.71 | HRH3 (0.53) | NOTUMHRH3KDM4EALDH1A1MAPK1 | |
| SCHEMBL2241300 | 0.71 | MAPK9 (0.58) | EGFRPIK3CDPIK3CAKDRMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |