Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31339220 | 0.82 | TSHR (0.47) | NUDT1TSHRTP53CASP1CDC7 | |
| SCHEMBL3515887 | 0.77 | TSHR (0.60) | NUDT1TSHRTP53CASP1CDC7 | |
| SCHEMBL29837473 | 0.77 | TSHR (0.60) | NUDT1TSHRTP53CASP1CDC7 | |
| SCHEMBL3290788 | 0.76 | TSHR (0.50) | NUDT1TSHRTP53CASP1CDC7 | |
| SCHEMBL277304 | 0.76 | TSHR (0.53) | NUDT1TSHRTP53CASP1CDC7 | |
| SCHEMBL31366358 | 0.75 | TSHR (0.46) | NUDT1TSHRTP53CASP1CDC7 | |
| SCHEMBL3879504 | 0.75 | GABRA1 (0.47) | TSHRGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL3347544 | 0.75 | OGA (0.40) | NUDT1TSHRTP53ALDH1A1KMT2A | |
| SCHEMBL13758656 | 0.74 | TSHR (0.52) | NUDT1TSHRTP53CASP1CDC7 | |
| SCHEMBL12447815 | 0.74 | TSHR (0.52) | NUDT1TSHRTP53CASP1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |