Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31366358 | 0.89 | TSHR (0.46) | TSHRNUDT1TP53CASP1CDC7 | |
| Isoquinoline SCHEMBL6846502 | 0.83 | TSHR (0.48) | TSHRTP53ALDH1A1KMT2AMAPT | |
| SCHEMBL3354068 | 0.82 | NUDT1 (0.43) | TSHRNUDT1TP53CASP1CDC7 | |
| SCHEMBL23826138 | 0.82 | KDM4E (0.60) | TSHRCASP1ALDH1A1KMT2AKDM4E | |
| SCHEMBL29837473 | 0.82 | TSHR (0.60) | TSHRNUDT1TP53CASP1CDC7 | |
| SCHEMBL3515887 | 0.82 | TSHR (0.60) | TSHRNUDT1TP53CASP1CDC7 | |
| SCHEMBL3290788 | 0.81 | TSHR (0.50) | TSHRNUDT1TP53CASP1CDC7 | |
| SCHEMBL277304 | 0.80 | TSHR (0.53) | TSHRNUDT1TP53CASP1CDC7 | |
| SCHEMBL13758656 | 0.79 | TSHR (0.52) | TSHRNUDT1TP53CASP1CDC7 | |
| SCHEMBL2568123 | 0.79 | CA12 (0.56) | TSHRNUDT1TP53CASP1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12215107-B1 | Pyrazino[1′,2′:1,5]pyrazolo[4,3-c] [2,6] naphthyridine compounds as CK2 inhibitors | King Faisal University (SA) | 2025-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12215107-B1 | Pyrazino[1′,2′:1,5]pyrazolo[4,3-c] [2,6] naphthyridine compounds as CK2 inhibitors | CSNK2A3, CKS2, CDK2 | TSHR 3490/4885NUDT1 3514/4885TP53 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.