Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 5/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14646665 | 0.88 | TMEM97 (0.56) | PREPACE2FKBP1ANPSR1TMEM97 | |
| SCHEMBL19621551 | 0.88 | TMEM97 (0.56) | PREPACE2FKBP1ANPSR1TMEM97 | |
| SCHEMBL791439 | 0.86 | PREP (0.57) | PREPACE2NPSR1ALDH1A1TP53 | |
| SCHEMBL13994810 | 0.86 | PREP (0.57) | PREPACE2NPSR1ALDH1A1TP53 | |
| SCHEMBL7598362 | 0.86 | TMEM97 (0.51) | PREPACE2FKBP1ATMEM97SIGMAR1 | |
| SCHEMBL7598366 | 0.86 | TMEM97 (0.51) | PREPACE2FKBP1ATMEM97SIGMAR1 | |
| SCHEMBL16983239 | 0.86 | PREP (0.55) | PREPACE2NPSR1TMEM97SIGMAR1 | |
| SCHEMBL1841001 | 0.86 | TMEM97 (0.51) | PREPACE2FKBP1ATMEM97SIGMAR1 | |
| SCHEMBL3119462 | 0.86 | DAGLB (0.49) | PREPACE2FKBP1ANPSR1TMEM97 | |
| SCHEMBL8342145 | 0.86 | DAGLB (0.49) | PREPACE2FKBP1ANPSR1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010067233-A1 | 1,2,4 TRIAZOLO [4, 3 -A] [1,5] BENZODIAZEPIN-5 (6H) -ONES AS AGONISTS OF THE CHOLECYSTOKININ-1 RECEPTOR (CCK-IR) | PFIZER INC. (US) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010067233-A1 | 1,2,4 TRIAZOLO [4, 3 -A] [1,5] BENZODIAZEPIN-5 (6H) -ONES AS AGONISTS OF THE CHOLECYSTOKININ-1 RECEPTOR (CCK-IR) | PFIZER INC. (US) | 2010-06-17 | — | — | WO | disclosed |