Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 7/20 | 0.36 |
| ▸ | NOS1 | P29475 | 7/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13537344 | 0.82 | HTR6 (0.45) | HTR6KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL3355685 | 0.80 | HTR7 (0.52) | HTR6KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL31324655 | 0.76 | HTR7 (0.46) | HTR6 | |
| SCHEMBL7253029 | 0.76 | HTR6 (0.42) | HTR6KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL1122077 | 0.76 | NOS3 (0.57) | HTR6NOS3NOS1NOS2 | |
| SCHEMBL15712192 | 0.76 | HTR7 (0.43) | HTR6KDM4EALDH1A1HPGDCYP3A4 | |
| SCHEMBL7252947 | 0.75 | HTR7 (0.53) | HTR6KDM4EALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL3359089 | 0.75 | HTR7 (0.43) | HTR6 | |
| SCHEMBL3345985 | 0.74 | PRKCI (0.44) | HTR6KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL2261753 | 0.74 | HTR6 (0.67) | HTR6NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |