⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14181105 | 0.94 | FKBP5 (0.33) | — | |
| SCHEMBL1270591 | 0.86 | — | — | |
| SCHEMBL6515035 | 0.72 | — | — | |
| SCHEMBL7098571 | 0.72 | GRIA1 (0.46) | — | |
| SCHEMBL2041036 | 0.65 | — | — | |
| SCHEMBL9923694 | 0.65 | — | — | |
| SCHEMBL4929162 | 0.64 | GRIA1 (0.55) | — | |
| SCHEMBL9925013 | 0.64 | — | — | |
| SCHEMBL31733866 | 0.64 | NPC1 (0.44) | — | |
| SCHEMBL6423927 | 0.63 | PNMT (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336315-B1 | Enzymatic encoding methods for efficient synthesis of large libraries | NUEVOLUTION AS (DK) | 2017-07-19 | — | — | EP | claimed |
| US-8097632-B2 | Blocking hedgehog protein transduction signal passageway using alkaloid steroid | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2012-01-17 | — | — | US | claimed |
| EP-2336315-A2 | Enzymatic encoding methods for efficient synthesis of large libraries | Nuevolution A/S (DK) | 2011-06-22 | — | — | EP | claimed |
| US-20080058298-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2008-03-06 | — | — | US | claimed |
| US-7291626-B1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2007-11-06 | — | — | US | claimed |
| US-20060142245-A1 | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto | JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 2006-06-29 | — | — | US | claimed |
| US-20060020020-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. (US) | 2006-01-26 | — | — | US | claimed |
| US-20040127474-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. (US) | 2004-07-01 | — | — | US | claimed |
| US-6432970-B2 | REDUCE CELL SENSITIVITY | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE | 2002-08-13 | — | — | US | claimed |
| JP-2002511415-A | — | — | 2002-04-16 | — | — | JP | claimed |
| US-20020006931-A1 | INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | THE JOHNS HOPKINS UNIVERSITY | 2002-01-17 | — | — | US | claimed |
| US-20010034337-A1 | Regulators of the hedgehog pathway, compositions and uses related thereto | CURIS, INC. | 2001-10-25 | — | — | US | claimed |
| EP-1143961-A2 | REGULATORS OF THE PTC OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | Ontogeny, Inc. (US) | 2001-10-17 | — | — | EP | claimed |
| EP-1067939-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) | 2001-01-17 | — | — | EP | claimed |
| WO-2000041545-A2 | REGULATORS OF THE PCT OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO | ONTOGENY, INC. (US) | 2000-07-20 | — | — | WO | claimed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | claimed |
| US-11702652-B2 | Enzymatic encoding methods for efficient synthesis of large libraries | NUEVOLUTION A/S (DK) | 2023-07-18 | — | — | US | disclosed |
| US-11602527-B2 | Methods of use of cyclopamine analogs | INFINITY PHARMACEUTICALS, INC. (US) | 2023-03-14 | — | — | US | disclosed |
| WO-1999052534-A1 | USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-10-21 | — | — | WO | disclosed |
| EP-0358558-A1 | Use of tetrahydro-4,5,6,7-furanopyridine derivatives in the production of medicaments for the treatment of obesity | SYNTHELABO (FR) | 1990-03-14 | — | — | EP | disclosed |