Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.31 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CPA1 | P15085 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418425 | 1.00 | TSHR (0.39) | TSHRMEN1KMT2AMMP1MMP2 | |
| SCHEMBL8422179 | 1.00 | TSHR (0.39) | TSHRMEN1KMT2AMMP1MMP2 | |
| SCHEMBL16310953 | 0.92 | TSHR (0.34) | TSHRMEN1KMT2AMMP1MMP2 | |
| SCHEMBL2336327 | 0.84 | KMT2A (0.45) | TSHRMEN1KMT2AMMP1MMP2 | |
| SCHEMBL8420441 | 0.84 | KMT2A (0.45) | TSHRMEN1KMT2AMMP1MMP2 | |
| SCHEMBL3355264 | 0.83 | LMNA (0.40) | TSHRMMP1MMP2MMP3MMP7 | |
| SCHEMBL11134509 | 0.83 | ALDH1A1 (0.37) | TSHRMEN1KMT2AMMP1MMP2 | |
| SCHEMBL4778798 | 0.83 | TSHR (0.36) | TSHRMEN1KMT2AMMP1MMP2 | |
| SCHEMBL23200430 | 0.79 | TSHR (0.40) | TSHRMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL4798136 | 0.79 | SLC1A3 (0.45) | MMP1MMP2MMP3MMP7TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2062874-B1 | Process and intermediates for the preparation of aliskiren | KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) | 2014-12-17 | — | — | EP | disclosed |
| EP-2189442-B1 | Process and intermediates for the preparation of aliskiren | KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) | 2014-10-01 | — | — | EP | disclosed |
| EP-2189442-A1 | Process and intermediates for the preparation of aliskiren | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2010-05-26 | — | — | EP | disclosed |
| EP-2062874-A1 | Process and intermediates for the preparation of aliskiren | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2009-05-27 | — | — | EP | disclosed |