Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 4/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP7 | P09237 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23200431 | 0.84 | ALDH1A1 (0.41) | LMNAALDH1A1FAAHMGLLTSHR | |
| SCHEMBL8422179 | 0.83 | TSHR (0.39) | LMNAALDH1A1TSHRTDP1MMP1 | |
| SCHEMBL3355256 | 0.83 | TSHR (0.39) | LMNAALDH1A1TSHRTDP1MMP1 | |
| SCHEMBL8418425 | 0.83 | TSHR (0.39) | LMNAALDH1A1TSHRTDP1MMP1 | |
| SCHEMBL4171918 | 0.82 | FAAH (0.40) | LMNAALDH1A1FAAHMGLLTSHR | |
| SCHEMBL16310953 | 0.77 | TSHR (0.34) | TSHRTDP1MMP1MMP2MMP3 | |
| SCHEMBL16236 | 0.74 | ALDH1A1 (0.45) | LMNAALDH1A1FAAHMGLLTSHR | |
| SCHEMBL8420441 | 0.74 | KMT2A (0.45) | LMNAALDH1A1TSHRSMN1; SMN2TDP1 | |
| SCHEMBL2336327 | 0.74 | KMT2A (0.45) | LMNAALDH1A1TSHRSMN1; SMN2TDP1 | |
| SCHEMBL29085533 | 0.73 | FAAH (0.39) | LMNAALDH1A1FAAHMGLLTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2189442-B1 | Process and intermediates for the preparation of aliskiren | KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) | 2014-10-01 | — | — | EP | disclosed |
| EP-2189442-A1 | Process and intermediates for the preparation of aliskiren | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2010-05-26 | — | — | EP | disclosed |