Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | MLYCD | O95822 | 2/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 3/20 | 0.60 |
| ▸ | CA1 | P00915 | 3/20 | 0.60 |
| ▸ | CA2 | P00918 | 3/20 | 0.60 |
| ▸ | CA7 | P43166 | 3/20 | 0.60 |
| ▸ | CA9 | Q16790 | 3/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18867940 | 1.00 | HPGD (0.80) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL517817 | 0.98 | HPGD (0.77) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL31334408 | 0.98 | HPGD (0.76) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL643480 | 0.94 | ALDH1A1 (0.69) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL5337680 | 0.92 | ALDH1A1 (0.67) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL16151536 | 0.90 | HPGD (0.65) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7734379 | 0.90 | HPGD (0.65) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL22305103 | 0.90 | CA12 (0.71) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL6985975 | 0.90 | CA12 (0.71) | HPGDALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL7132525 | 0.89 | HPGD (1.00) | HPGDALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | Valo Health, LLC | 2023-04-13 | — | — | US | disclosed |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | VALO HEALTH, INC. (US) | 2022-10-25 | — | — | US | disclosed |
| WO-2021121420-A1 | BENZOPYRAZOLE COMPOUND AND INTERMEDIATE, PREPARATION METHOD, AND APPLICATION THEREOF | 江苏凯迪恩医药科技有限公司 | 2021-06-24 | — | — | WO | disclosed |
| CN-108033694-A | Novel silicate cement and preparation method thereof | 天津山水水泥有限公司 | 2018-05-15 | — | — | CN | disclosed |
| CN-108033694-A | Novel silicate cement and preparation method thereof | 天津山水水泥有限公司 | 2018-05-15 | — | — | CN | disclosed |
| CN-107417767-A | Dipeptide compound, its preparation method and the application of piperidines or piperazine structure | 杭州市西溪医院 | 2017-12-01 | — | — | CN | disclosed |
| US-9718787-B2 | Poly (ADP-ribose) polymerase inhibitor | CHENGDU DI'AO PHARMACEUTICAL GROUP CO., LTD. (CN) | 2017-08-01 | — | — | US | disclosed |
| CN-106866625-A | The preparation method of ketanserin | 上海鼎雅药物化学科技有限公司 | 2017-06-20 | — | — | CN | disclosed |
| US-20170137341-A1 | FLUORINATION METHOD | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2017-05-18 | — | — | US | disclosed |
| US-20150368205-A1 | POLY (ADP-RIBOSE) POLYMERASE INHIBITOR | CHENGDU DI'AO PHARMACEUTICAL GROUP CO., LTD. (CN) | 2015-12-24 | — | — | US | disclosed |
| US-5280032-A | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1994-01-18 | — | — | US | disclosed |
| US-5225412-A | Antipsychotic | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-06 | — | — | US | disclosed |
| EP-0511610-A1 | Benzisothiazole- and benzisoxazole-3-carboxamides, a process for their preparation and their use as antipsychotic medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-04 | — | — | EP | disclosed |
| US-5143923-A | Psychological disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-09-01 | — | — | US | disclosed |
| US-4990614-A | N-heterocyclic amides | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-02-05 | — | — | US | disclosed |
| EP-0383281-A1 | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1990-08-22 | — | — | EP | disclosed |
| EP-0311517-A2 | Amide compound having glutamate receptor inhibiting activity | Takeda Chemical Industries, Ltd. (JP) | 1989-04-12 | — | — | EP | disclosed |
| EP-0124476-B1 | CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1988-06-22 | — | — | EP | disclosed |
| US-4559349-A | TREATMENT OF PHYCHOSIS | CIBA GEIGY CORPORATION (US) | 1985-12-17 | — | — | US | disclosed |
| EP-0124476-A1 | Carboxamides, process for their preparation and pharmaceutical preparations containing them | CIBA-GEIGY AG (CH) | 1984-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | NAMPT, NAPRT, NNMT | HPGD 105/4885ALDH1A1 265/4885MEN1 2895/4885 |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | NAMPT, NAPRT, NNMT | HPGD 105/4885ALDH1A1 265/4885MEN1 2895/4885 |
| US-20170137341-A1 | FLUORINATION METHOD | F13B, PPARG, PGC | HPGD 2190/4885ALDH1A1 905/4885MEN1 2644/4885 |
| US-20150368205-A1 | POLY (ADP-RIBOSE) POLYMERASE INHIBITOR | PARP1, PARP2, PARP11 | HPGD 509/4885ALDH1A1 607/4885MEN1 4081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.