Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | KRAS | P01116 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL18941266 | 0.96 | HTR7 (0.46) | HTR7CYP1A2PLGPLAUSLC6A2 | |
| SCHEMBL2479169 | 0.91 | HTR7 (0.47) | HTR7CYP1A2PLGPLAUSLC6A2 | |
| SCHEMBL15712293 | 0.88 | HTR7 (0.62) | HTR7CYP1A2CYP19A1MAPTMEN1 | |
| SCHEMBL2420811 | 0.88 | CYP1A2 (0.53) | HTR7CYP1A2PLGPLAUSLC6A2 | |
| SCHEMBL29167245 | 0.85 | MAPT (0.51) | HTR7PLGPLAUSLC6A2CYP19A1 | |
| SCHEMBL30672928 | 0.85 | PLG (0.46) | HTR7PLGPLAUSLC6A2CYP19A1 | |
| SCHEMBL27768896 | 0.85 | KRAS (0.47) | HTR7CYP1A2PLGPLAUSLC6A2 | |
| SCHEMBL16371052 | 0.85 | PLG (0.46) | HTR7PLGPLAUSLC6A2CYP19A1 | |
| SCHEMBL30785020 | 0.85 | MAPT (0.51) | HTR7PLGPLAUSLC6A2CYP19A1 | |
| SCHEMBL30410682 | 0.85 | HTR6 (0.51) | HTR7CYP1A2PLGPLAUSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| US-5328922-A | Anxiolytic and antidepressant activity | BEECHAM GROUP P.L.C. (GB) | 1994-07-12 | — | — | US | disclosed |
| WO-1993018026-A1 | INDOLE UREAS AS 5-HT1C RECEPTOR ANTOGONISTS | BEECHAM GROUP PLC (GB) | 1993-09-16 | — | — | WO | disclosed |
| EP-0550507-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005170-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | disclosed |