Trapidil

Trapidil

SCHEMBL33563

CCN(CC)c1cc(C)nc2ncnn12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 1.00
LMNA P02545 1/20 1.00
CYP1A2 P05177 1/20 1.00
ENPP1 P22413 1/20 0.69
TP53 P04637 1/20 0.64
L3MBTL1 Q9Y468 1/20 0.64
ALDH1A1 P00352 3/20 0.57
NPSR1 Q6W5P4 1/20 0.55
TSHR P16473 3/20 0.53
BRD4 O60885 1/20 0.51
ATM Q13315 1/20 0.50
GAA P10253 2/20 0.48
HTT P42858 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
KDM4E B2RXH2 4/20 0.48
PKM P14618 1/20 0.48
HPGD P15428 1/20 0.48
HSD17B10 Q99714 1/20 0.48
MAPT P10636 1/20 0.48
MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trapidil SCHEMBL19438921 1.00 MAPK1 (1.00) MAPK1LMNACYP1A2ENPP1TP53
Trapidil SCHEMBL6447214 0.98 MAPK1 (0.97) MAPK1LMNACYP1A2ENPP1TP53
Trapidil SCHEMBL997509 0.95 MAPK1 (0.91) MAPK1LMNACYP1A2ENPP1TP53
SCHEMBL21164287 0.91 MAPK1 (0.83) MAPK1LMNACYP1A2ENPP1TP53
SCHEMBL2027089 0.81 ENPP1 (1.00) MAPK1LMNACYP1A2ENPP1TP53
SCHEMBL23875145 0.75 ENPP1 (0.65) MAPK1LMNACYP1A2ENPP1TP53
SCHEMBL13064173 0.75 ALDH1A1 (0.62) MAPK1LMNACYP1A2ENPP1TP53
SCHEMBL23875139 0.74 ENPP1 (0.63) MAPK1LMNACYP1A2ENPP1TP53
SCHEMBL7706332 0.73 LMNA (0.58) MAPK1LMNACYP1A2ENPP1TP53
SCHEMBL259453 0.73 ALDH1A1 (1.00) MAPK1LMNACYP1A2ENPP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8107 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260041336-A1 PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK NEW YORK UNIVERSITY (US) 2026-02-12 US claimed
EP-4674894-A2 COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES Hemoteq AG (DE) 2026-01-07 EP claimed
US-20250387396-A1 TREATING EXTRAPYRAMIDAL SYNDROME USING TRAPIDIL SINOPIA BIOSCIENCES INC (US) 2025-12-25 US claimed
EP-4663688-A2 CROSSLINKERS Hemoteq AG (DE) 2025-12-17 EP claimed
EP-4630413-A1 FLAVANONE COMPOUNDS AND THEIR USE AS FLAVOR MODIFIERS Firmenich Incorporated (US) 2025-10-15 EP claimed
US-20250271426-A1 REDUCTION OF BITTER TASTE OF ACTIVE PHARMACEUTICAL INGREDIENTS AND RELATED ASSAYS AND SCREENING METHODS FIRMENICH INCORPORATED (US) 2025-08-28 US claimed
EP-3442538-B1 TREATING LEVODOPA-INDUCED DYSKINESIA USING TRAPIDIL SINOPIA BIOSCIENCES INC (US) 2025-07-23 EP claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-12285488-B2 Oral dosage form containing theobromine-free cocoa LTS LOHMANN THERAPIE-SYSTEME AG (DE) 2025-04-29 US claimed
US-12268691-B2 Treating extrapyramidal syndrome using trapidil SINOPIA BIOSCIENCES, INC. (US) 2025-04-08 US claimed
US-5288503-A WATER-PERMEABLE DIFFUSION BARRIER OF POLYVINYL ALCOHOL SRCHEM INCORPORATED (US) 1994-02-22 US claimed
WO-1993023082-A1 TOPICAL OPHTHALMIC COMPOSITIONS COMPRISING A COMBINATION OF CALCIUM ANTAGONISTS WITH KNOWN ANTIGLAUCOMA AGENTS ALCON LABORATORIES, INC. (US) 1993-11-25 WO claimed
US-5260066-A Cryogel bandage containing therapeutic agent SRCHEM INCORPORATED (US) 1993-11-09 US claimed
EP-0568451-A1 Thermoplastic polymer composition and medical devices made of the same TERUMO KABUSHIKI KAISHA (JP) 1993-11-03 EP claimed
EP-0518940-A4 METHOD AND APPARATUS FOR TREATMENT OF TUBULAR ORGANS 1993-05-12 EP claimed
EP-0518940-A1 METHOD AND APPARATUS FOR TREATMENT OF TUBULAR ORGANS ENDOLUMINAL THERAPEUTICS, INC. (US) 1992-12-23 EP claimed
WO-1991012846-A1 METHOD AND APPARATUS FOR TREATMENT OF TUBULAR ORGANS SLEPIAN MARVIN J (US) 1991-09-05 WO claimed
EP-0301423-A1 Pharmaceutical compositions containing trapidil, and process for their preparation CHIESI FARMACEUTICI S.p.A. (IT) 1989-02-01 EP claimed
EP-0075029-B1 AGENT FOR TREATING CHRONIC OBLITERATIVE LUNG DISEASE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1986-10-29 EP claimed
EP-0075029-A1 AGENT FOR TREATING CHRONIC OBLITERATIVE LUNG DISEASE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1983-03-30 EP claimed