Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610244 | 0.79 | EGLN2 (0.39) | LMNACYP1A2MAPK1ALDH1A1KDM4E | |
| Trapidil SCHEMBL33563 | 0.73 | MAPK1 (1.00) | LMNACYP1A2MAPK1TP53L3MBTL1 | |
| Trapidil SCHEMBL19438921 | 0.73 | MAPK1 (1.00) | LMNACYP1A2MAPK1TP53L3MBTL1 | |
| SCHEMBL6468861 | 0.73 | ALDH1A1 (0.47) | LMNAALDH1A1KDM4EGAARCE1 | |
| Trapidil SCHEMBL6447214 | 0.72 | MAPK1 (0.97) | LMNACYP1A2MAPK1TP53L3MBTL1 | |
| Trapidil SCHEMBL997509 | 0.70 | MAPK1 (0.91) | LMNACYP1A2MAPK1TP53L3MBTL1 | |
| SCHEMBL7899954 | 0.70 | ALDH1A1 (0.52) | MAPK1ALDH1A1KDM4EGAARCE1 | |
| SCHEMBL7706336 | 0.68 | LMNA (0.33) | LMNACYP1A2MAPK1GSK3B | |
| SCHEMBL10406955 | 0.67 | ALDH1A1 (0.50) | ALDH1A1KDM4EGAARCE1GLA | |
| SCHEMBL9555662 | 0.67 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAARCE1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369065-B1 | CEREBROVASCULAR AND CARDIOVASCULAR DISORDERS | UCB S.A. (BE) | 2002-04-09 | — | — | US | claimed |
| US-6369065-B1 | CEREBROVASCULAR AND CARDIOVASCULAR DISORDERS | UCB S.A. (BE) | 2002-04-09 | — | — | US | disclosed |