Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.77 |
| ▸ | HPGD | P15428 | 8/20 | 0.77 |
| ▸ | GLA | P06280 | 7/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.77 |
| ▸ | GAA | P10253 | 6/20 | 0.77 |
| ▸ | CA9 | Q16790 | 5/20 | 0.77 |
| ▸ | CA12 | O43570 | 4/20 | 0.77 |
| ▸ | CA1 | P00915 | 4/20 | 0.77 |
| ▸ | CASP1 | P29466 | 3/20 | 0.77 |
| ▸ | CASP7 | P55210 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL4176892 | 0.99 | ALDH1A1 (0.75) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| Glycine SCHEMBL4627607 | 0.99 | ALDH1A1 (0.75) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| Beta-Alanine SCHEMBL4160809 | 0.91 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| Acetic Acid SCHEMBL3998167 | 0.90 | ALDH1A1 (0.84) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL37677 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL28806970 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL29645144 | 0.88 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL6424932 | 0.88 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| Hydrochloric Acid SCHEMBL4170610 | 0.87 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| Hydrochloric Acid SCHEMBL567469 | 0.86 | ALDH1A1 (0.96) | ALDH1A1KDM4EHPGDGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015024576-A1 | POLYMER-BOUND IODINE AS A QUENCHER FOR FLUORESCENCE MEASUREMENTS | TESTO AG (DE) | 2015-02-26 | — | — | WO | claimed |
| CN-102994387-A | High throughput screening method of aminopeptidase and high-yield strain thereof | TIANJIN INST IND BIOTECHNOLOGY | 2013-03-27 | — | — | CN | claimed |
| US-8097404-B2 | Composition and method for cell permeabilization comprising N-octyl-β-D-glucopyranoside, sodium polyphosphates, rubidium chloride and/or lithium chloride for detecting living cells on a membrane | MILLIPORE CORPORATION (US) | 2012-01-17 | — | — | US | claimed |
| EP-2107119-B1 | Composition for cell permeabilization comprising NOG, HMP, rubidium chloride and/or lithium chloride for detecting living cells on a membrane | MILLIPORE CORP (US) | 2010-05-12 | — | — | EP | claimed |
| EP-2107119-A1 | Composition for cell permeabilization comprising NOG, HMP, rubidium chloride and/or lithium chloride for detecting living cells on a membrane | Millipore Corporation (US) | 2009-10-07 | — | — | EP | claimed |
| US-20090246822-A1 | Composition for cell permeabilization comprising NOG, HMP, rubidium chloride and/or lithium chloride for detecting living cells on a membrane | EMD MILLIPORE CORPORATION | 2009-10-01 | — | — | US | claimed |
| EP-1352083-B1 | COMPOSITIONS AND METHODS FOR DETECTING TARGET MICROORGANISMS IN A SAMPLE | BIOCONTROL SYSTEMS INC (US) | 2005-10-26 | — | — | EP | claimed |
| EP-0496680-B1 | Procedure and medium to identify bacteria of the genus Listeria | BIO MERIEUX (FR) | 1995-09-06 | — | — | EP | claimed |
| WO-1995000660-A1 | METHOD FOR ASSESSING MICROORGANISM VIABILITY | CHEMUNEX (FR) | 1995-01-05 | — | — | WO | claimed |
| US-5330889-A | Colorimetric, fluorescence, enzymatic hydrolysis of substrate | BIO MERIEUX (FR) | 1994-07-19 | — | — | US | claimed |
| EP-0496680-A1 | Procedure and medium to identify bacteria of the genus Listeria | BIO MERIEUX, Société anonyme (FR) | 1992-07-29 | — | — | EP | claimed |
| JP-5030995-A | — | — | None | — | — | JP | disclosed |
| WO-2015024576-A1 | POLYMER-BOUND IODINE AS A QUENCHER FOR FLUORESCENCE MEASUREMENTS | TESTO AG (DE) | 2015-02-26 | — | — | WO | disclosed |
| CN-102994387-A | High throughput screening method of aminopeptidase and high-yield strain thereof | TIANJIN INST IND BIOTECHNOLOGY | 2013-03-27 | — | — | CN | disclosed |
| US-8097404-B2 | Composition and method for cell permeabilization comprising N-octyl-β-D-glucopyranoside, sodium polyphosphates, rubidium chloride and/or lithium chloride for detecting living cells on a membrane | MILLIPORE CORPORATION (US) | 2012-01-17 | — | — | US | disclosed |
| EP-0333560-B1 | Process for quantitative determination of micro organismes | CHEMUNEX (FR) | 1994-04-27 | — | — | EP | disclosed |
| JP-H0530995-A | IDENTIFICATION AND MEDIUM FOR BACTERIUM OF GENUS LISTERIA | BIO MERIEUX | 1993-02-09 | — | — | JP | disclosed |
| EP-0496680-A1 | Procedure and medium to identify bacteria of the genus Listeria | BIO MERIEUX, Société anonyme (FR) | 1992-07-29 | — | — | EP | disclosed |
| WO-1989008714-A1 | QUALITITIVE OR QUANTITITIVE PROCESS FOR RESEARCHING MICROORGANISMS, INSTALLATION FOR APPLICATION OF SAID PROCESS | CHEMUNEX (FR) | 1989-09-21 | — | — | WO | disclosed |
| EP-0333560-A1 | Process for quantitative determination of micro organismes | CHEMUNEX (FR) | 1989-09-20 | — | — | EP | disclosed |