Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL336017 | 0.83 | HSP90AA1 (0.36) | ALDH1A1KIF11ADRB2ADRB1ADRB3 | |
| SCHEMBL335541 | 0.72 | KMT2A (0.38) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL15540225 | 0.71 | KCNN4 (0.44) | KCNN4SMN1; SMN2LMNAAKR1C3AKR1C2 | |
| SCHEMBL15539304 | 0.71 | KCNN4 (0.44) | KCNN4SMN1; SMN2LMNAAKR1C3AKR1C2 | |
| SCHEMBL2395440 | 0.70 | KCNN4 (0.50) | KCNN4SMN1; SMN2KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL18683500 | 0.64 | LMNA (0.39) | LMNAADRB2ADRB1ADRB3 | |
| SCHEMBL24011029 | 0.64 | ADRB2 (0.47) | KCNN4SMN1; SMN2ALDH1A1ADRB2ADRB1 | |
| SCHEMBL17894131 | 0.63 | KCNN4 (0.43) | KCNN4AKR1C3AKR1C2KCNE1KCNQ1 | |
| SCHEMBL19448777 | 0.63 | KCNN4 (0.39) | KCNN4AKR1C3AKR1C2KCNE1KCNQ1 | |
| SCHEMBL17902412 | 0.63 | KCNN4 (0.43) | KCNN4AKR1C3AKR1C2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097758-B2 | Isoserine derivatives for use as coagulation factor IXa inhibitors | SANOFI-AVENTIS (FR) | 2012-01-17 | — | — | US | disclosed |