Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 5/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.37 |
| ▸ | SYK | P43405 | 3/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359057 | 0.91 | SYK (0.41) | ALKZAP70SYKINSRKCNH2 | |
| SCHEMBL3360058 | 0.83 | JAK3 (0.40) | ALKZAP70SYKIKBKBJAK2 | |
| SCHEMBL3358971 | 0.81 | ZAP70 (0.47) | ZAP70JAK2JAK1JAK3 | |
| SCHEMBL3358781 | 0.81 | SYK (0.41) | ZAP70SYKJAK2JAK3 | |
| SCHEMBL3363275 | 0.80 | ZAP70 (0.38) | ZAP70SYKJAK3AXLTYRO3 | |
| SCHEMBL1045396 | 0.80 | ZAP70 (0.60) | ALKZAP70SYKJAK2JAK1 | |
| SCHEMBL3362704 | 0.79 | ZAP70 (0.40) | ALKZAP70SYKJAK2JAK3 | |
| SCHEMBL3362371 | 0.79 | SYK (0.38) | ZAP70SYKAXLTYRO3MERTK | |
| SCHEMBL3362286 | 0.79 | ALK (0.36) | ALKZAP70SYKIKBKBJAK2 | |
| SCHEMBL3359641 | 0.79 | ZAP70 (0.41) | ZAP70SYKJAK2JAK3ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |