Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | CD63 | P08962 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 5/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | YES1 | P07947 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358415 | 0.85 | SYK (0.41) | SYKCD63AURKAZAP70BRD4 | |
| SCHEMBL3359180 | 0.82 | MAPT (0.50) | SYKCD63AURKAZAP70AURKC | |
| SCHEMBL3357802 | 0.81 | ALK (0.39) | SYKZAP70JAK2JAK3 | |
| SCHEMBL3362709 | 0.80 | SYK (0.45) | SYKCD63AURKAZAP70BRD4 | |
| SCHEMBL3359647 | 0.80 | MAPT (0.43) | SYKCD63AURKAZAP70AURKC | |
| SCHEMBL3359805 | 0.79 | ZAP70 (0.42) | SYKCD63AURKAZAP70AURKC | |
| SCHEMBL3362714 | 0.79 | ABL1 (0.45) | SYKCD63AURKAZAP70AURKC | |
| SCHEMBL3361347 | 0.79 | ZAP70 (0.42) | SYKCD63AURKAZAP70AURKC | |
| SCHEMBL1047722 | 0.79 | ZAP70 (0.66) | SYKZAP70 | |
| SCHEMBL3358764 | 0.78 | SYK (0.42) | SYKCD63AURKAZAP70BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |