Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3360058 | 0.91 | JAK3 (0.40) | SYKALKZAP70 | |
| SCHEMBL3357802 | 0.91 | ALK (0.39) | SYKALKZAP70INSRKCNH2 | |
| SCHEMBL3360308 | 0.87 | SYK (0.44) | SYKALKZAP70INSR | |
| SCHEMBL3362371 | 0.82 | SYK (0.38) | SYKZAP70 | |
| SCHEMBL3363275 | 0.81 | ZAP70 (0.38) | SYKZAP70 | |
| SCHEMBL3358854 | 0.81 | ALK (0.53) | SYKALKZAP70INSRKCNH2 | |
| SCHEMBL1048357 | 0.79 | ZAP70 (0.57) | SYKALKZAP70 | |
| SCHEMBL3362356 | 0.79 | BTK (0.38) | SYKALKZAP70 | |
| SCHEMBL3359025 | 0.78 | SYK (0.42) | SYKALKZAP70 | |
| SCHEMBL3358388 | 0.78 | MAP3K12 (0.39) | SYKZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |