Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.43 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5209430 | 0.84 | MAPT (0.44) | IDO1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1145768 | 0.83 | IDO1 (0.57) | LTA4HIDO1APPALDH1A1CYP3A4 | |
| SCHEMBL23963855 | 0.81 | IDO1 (0.37) | IDO1APPMAPTMEN1KMT2A | |
| SCHEMBL24332758 | 0.81 | IDO1 (0.41) | IDO1APPMAPTMEN1KMT2A | |
| SCHEMBL22199500 | 0.78 | CYP1A2 (0.59) | MAPTKMT2AALDH1A1CYP3A4LMNA | |
| SCHEMBL514636 | 0.76 | BCHE (0.53) | ALDH1A1TSHR | |
| SCHEMBL25057436 | 0.76 | IDO1 (0.38) | IDO1APPALDH1A1CYP3A4TSHR | |
| SCHEMBL17057778 | 0.76 | NPC1 (0.54) | LTA4HMEN1KMT2ATSHRLMNA | |
| SCHEMBL21765871 | 0.76 | HRH3 (0.42) | IDO1MAPTMEN1KMT2ALMNA | |
| SCHEMBL14139588 | 0.74 | LMNA (0.53) | MAPTMEN1KMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115611790-A | Preparation method of methylthio methyl phenyl ether | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2023-01-17 | — | — | CN | claimed |
| CN-115611790-A | Preparation method of methylthio methyl phenyl ether | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2023-01-17 | — | — | CN | disclosed |
| US-8912150-B2 | Ribosome structure and protein synthesis inhibitors | MELINTA THERAPEUTICS, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-20140066623-A1 | Ribosome Structure and Protein Synthesis Inhibitors | MELINTA THERAPEUTICS, LLC | 2014-03-06 | — | — | US | disclosed |
| US-20100204253-A1 | Ribosome Structure and Protein Synthesis Inhibitors | YALE UNIVERSITY (US) | 2010-08-12 | — | — | US | disclosed |
| US-7666849-B2 | ligands that are designed to specifically kill or inhibit the growth of any target organism | RIB-X PHARMACEUTICALS, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-20050272681-A1 | ligands that are designed to specifically kill or inhibit the growth of any target organism | YALE UNIVERSITY (US) | 2005-12-08 | — | — | US | disclosed |
| US-6947845-B2 | Method of identifying molecules that bind to the large ribosomal subunit | YALE UNIVERSITY (US) | 2005-09-20 | — | — | US | disclosed |
| US-20050036997-A1 | Molecular modeling of the binding sites for anisomycin, azithromycin, erythromycin, linezolid, tylosin, carbomycin A, spiramycin, virginiamycin, sparsomycin and blasticidin using the Haloarcular marismortui large ribosomal subunit; drug design and drug screening | YALE UNIVERSITY (US) | 2005-02-17 | — | — | US | disclosed |
| EP-1308457-A1 | Ribosome structure and protein synthesis inhibitors | YALE UNIVERSITY (US) | 2003-05-07 | — | — | EP | disclosed |