Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.46 |
| ▸ | SYK | P43405 | 4/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359512 | 0.85 | ZAP70 (0.51) | ZAP70SYKTBK1 | |
| SCHEMBL3359250 | 0.85 | ZAP70 (0.53) | ZAP70SYKTBK1JAK2 | |
| SCHEMBL3359784 | 0.84 | ZAP70 (0.51) | ZAP70SYKALKINSR | |
| SCHEMBL3360152 | 0.83 | ZAP70 (0.64) | ZAP70SYK | |
| SCHEMBL3360670 | 0.83 | ZAP70 (0.48) | ZAP70SYKTLR9TLR8TLR7 | |
| SCHEMBL3359436 | 0.83 | ZAP70 (0.48) | ZAP70SYKTLR9TLR8TLR7 | |
| SCHEMBL3358701 | 0.82 | ZAP70 (0.47) | ZAP70SYKTLR9TLR8TLR7 | |
| SCHEMBL1045988 | 0.81 | ZAP70 (0.70) | ZAP70SYKTLR9TLR8TLR7 | |
| SCHEMBL3362099 | 0.81 | ZAP70 (0.45) | ZAP70SYKTLR9TLR8TLR7 | |
| SCHEMBL3362358 | 0.81 | ZAP70 (0.45) | ZAP70SYKTLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |