Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 4/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.35 |
| ▸ | INSR | P06213 | 2/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362284 | 0.85 | ZAP70 (0.39) | ZAP70SYKALKINSRTLR9 | |
| SCHEMBL1158376 | 0.83 | SYK (0.36) | ZAP70GSK3BSYKALKINSR | |
| SCHEMBL3358232 | 0.81 | ZAP70 (0.46) | ZAP70SYKALKINSRTLR9 | |
| SCHEMBL3359635 | 0.81 | ZAP70 (0.53) | ZAP70GSK3BSYKALKTLR9 | |
| SCHEMBL1048447 | 0.81 | ZAP70 (0.68) | ZAP70GSK3BSYKTLR9TLR8 | |
| SCHEMBL3362403 | 0.81 | ZAP70 (0.68) | ZAP70GSK3BSYKTLR9TLR8 | |
| SCHEMBL1158541 | 0.81 | ZAP70 (0.49) | ZAP70SYKALKINSRBRD4 | |
| SCHEMBL3362166 | 0.81 | ZAP70 (0.49) | ZAP70SYKALKINSRTLR9 | |
| SCHEMBL3360670 | 0.81 | ZAP70 (0.48) | ZAP70SYKALKINSRTLR9 | |
| SCHEMBL3359111 | 0.81 | ZAP70 (0.52) | ZAP70GSK3BSYKTLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |